【摘要】目的探讨不同金属烤瓷材料对龈沟液血管内皮生长因子(VEGF)水平的影响。方法把采用镍铬合金(T1组)、钛合金(T2组)、钯金合金(T3组)烤瓷冠修复的患者(30颗牙)分为3组，用滤纸条采取修复前和修复后6个月修复牙龈沟液，检测龈沟液量并用酶联免疫吸附法检测 VEGF 的浓度。结果患牙采用金属烤瓷冠修复前，3组龈沟液量的差异无统计学意义(P>0.05)，3组龈沟液VEGF水平无统计学意义(P>0.05)。同修复前相比，修复后T1及T2组龈沟液量和龈沟液中VEGF水平增高均有统计学意义。T3组龈沟液量和龈沟液中VEGF水平修复前后均无统计学意义(P>0.05)。T3组修复后与T1、T2组比较均有统计学意义。结论不同种类金属烤瓷基底材料对牙周组织的刺激程度不同,牙科合金材料对龈沟液血管内皮生长因子水平有影响。
【关键词】 金属烤瓷;牙龈炎;龈沟液;血管内皮生长因子
[Abstract]ObjectiveTo study the effects of different alloys to the periodontal tissue health.MethodsA total of 30 cases were divided into 3 groups: T1，Ni-Cr alloy;T2 : Ti alloy;T3 : Pd-Au alloy respectively. The gingival cervicular fluid(GCF)of the re-operation and the operative 6-months after therapy were taken by using periopaper to detect the volume of GCF and the concentration of VEGF through ELISA.ResultsBefore the operation，there is no statistical significance in volume(F=2.766，P>0.05)and VEGF level(F=0.250，P>0.05)of the three GCF，but after 6-months the volumes of GCF in group T1,T2 and T3 were (0.718±0.049)μl，(0.648±0.319)μl，( 0.648±0.319)μl and (0.609±0.111)μl; the VEGF levels were (39.856±10.499) pg/ml，(39.893±8.848) pg/ml and ( 22.162±2.972) pg/ml. Compared with the post-operation，the volume of G
